Seronegative rheumatoid is a group of rheumatoid arthritis characterized by several negative rheumatoid-related markers. These markers are rheumatoid factor and anti-citrullinated protein antibodies, etc., and are usually characterized by symptoms such as inflammation of the joints. Rarely, this type of disease may involve the heart in severe cases, with complications such as rheumatic heart disease and interstitial lung degeneration. If rheumatoid arthritis is left untreated, symptoms such as deformation of the affected joints may occur. Non-steroidal anti-inflammatory drugs (NSAIDs) such as etoricoxib, glucocorticosteroids such as prednisone acetate tablets, and anti-rheumatic drugs such as methotrexate and leflunomide can be used to control the symptoms and to slow down the progression of the disease as prescribed by the doctor. If you have seronegative rheumatoid disease, you should consult the rheumatology and immunology department and follow the doctor’s instructions for reasonable treatment.