Botulinum toxin is suitable for those who are reluctant to undergo surgery, have concerns about surgery, are not suitable for surgery, and also for those who still have fine wrinkles after facial wrinkle removal surgery. It is also suitable for those who still have small wrinkles after facial wrinkle reduction. Young patients with no obvious skin laxity and short upper lip with open smile are also suitable for this treatment. Botulinum toxin to get rid of wrinkles is relatively safe, but there are also the following surgical risks: 1, granuloma: rare, and difficult to treat, may require surgical resection; 2, local bruising: manifested as bruising, which occurs less often, may last for 1-2 weeks, and generally can disappear on its own; 3, Botulinum toxin is very useful for the nerves, and if injected frequently, it will lead to numbness of the nerve, and in serious cases, it will also damage the facial nerves, resulting in crooked corners of the mouth. And long-term use will appear premature aging symptoms, it is recommended to inject 2-3 times a year; 4, a very small number of allergic reactions to botulinum toxin, usually using adrenaline and hormone drugs. Candidates for this operation, the day of the operation should pay attention to avoid washing the face or the injection site of water, try to use cold water to wash the affected area within 3 days after the operation, and avoid massage within 1 week. It should be noted that, although the effect of Botox wrinkle removal is better, but in pregnancy, breastfeeding, physiological period, within six months of the preparation for the pregnancy plan of women, or recently carried out other surgical treatments, injections of fillers, and allergic to the crowd, is not recommended to inject Botox.