Nano knife ablative treatment itself selects patients who are relatively advanced, and the effect of it cannot be said to be cured by one treatment of Nano knife, which is unrealistic. According to foreign data, the treatment of pancreatic cancer, that is, the usual range of treatment for locally advanced pancreatic cancer, the effect of treatment time is mostly extended for 3-6 months, through their statistics, the survival rate of more than 2 years can reach about 50%, indicating that the treatment effect is still very encouraging. The effect of treatment has a lot to do with the patient’s choice. For the treatment of these locally advanced pancreatic cancers, the emphasis is still on chemotherapy or radiotherapy in combination, that is, after they are treated, the stage is lowered, and then nano-knife ablation is chosen later. The effect of combined treatment may be better, as one type of treatment alone may not be ideal, and nano-knife ablation has given us a better choice. For those who cannot be resected and are not satisfied with the results of chemotherapy and radiotherapy, nano-knife ablation is a relatively good treatment option that can be expected.