The main cause of unsteadiness with the eyes closed is a disease of the central and peripheral nerves. The more common ones are diseases of the spinal cord, and diseases of the cerebellum. The spinal cord and cerebellum are responsible for the body’s balance, and if a lesion occurs, it can cause the body to stand unsteadily with the eyes closed or with the eyes open. Patients with this condition need to go to a hospital neurology department for a detailed examination, such as an MRI, and related nerve conduction tests to determine where the root cause of the disease lies. If necessary, apply drugs that nourish brain cells, nerve nourishing drugs, and symptomatic treatment, such as cerebroprotein hydrolysate, cytarabine, and gangliosides, and a series of other drugs. Apply drugs that improve circulation, such as blood sparing and blood plugging, for improving circulation and symptomatic treatment.