The HFMD vaccine usually requires 2 doses, which need to be given one month apart. Hand, foot and mouth disease vaccine is a vaccine used to prevent hand, foot and mouth disease induced by Ev71 (i.e. enterovirus 71) infection, a total of 2 shots are required, and between each dose, an interval of 1 month is required. Generally, children can be vaccinated when they reach 6 months of age, and it is generally recommended that children should be vaccinated before they reach 3 to 5 years of age. The earlier the child is vaccinated, the better the results will be, so it is recommended that children be vaccinated before they reach 5 years of age as much as possible. The HFMD vaccination does not prevent your child from contracting HFMD, but it can prevent your child from contracting severe forms of HFMD. Common adverse reactions to HFMD vaccination are redness, swelling, heat and pain, nodules at the site of vaccination, and may cause fever, and are contraindicated in people who are allergic to HFMD vaccine. In addition, there are certain contraindications to HFMD vaccination, and parents are advised to consult a specialist before vaccinating their children.