Meningitis is relatively common in newborns and is mostly caused by bacterial infections. Whether neonatal meningitis will leave sequelae after cure depends on the state of the newborn at birth, the type of infecting bacteria, the severity of the disease, and whether there are comorbidities and whether treatment is timely. Some newborns with severe disease may have epilepsy, mental retardation and motor retardation after cure. Neonatal meningitis requires prompt treatment, and most newborns are cured without sequelae. However, if the newborn is born premature and has Gram-negative bacterial infection, or if it is combined with ventriculitis, subdural effusion, or hydrocephalus, or if the treatment is not timely or complete, there may be sequelae. Some newborns may show characteristic manifestations of hydrocephalus, such as seizures, delayed mental development, and possibly impaired consciousness. If meningitis damages the motor center, sequelae of motor impairment such as lameness and difficulty in grasping objects may occur. Newborns with lumbosacral spinal cord involvement may show abnormalities in stool and urine, such as incontinence. Therefore, newborns with meningitis need timely treatment, such as the application of antibiotics, including ceftriaxone, cefotaxime, gentamicin, etc., and neurotrophic drugs, such as olanzapine and methylcobalamin. If the newborn is complicated by subdural fluid and ventriculitis, subdural puncture or lateral ventricular drainage is also required. In case of fever and jet vomiting, symptomatic treatment with drugs such as ibuprofen and mannitol can be applied. Neonatal meningitis can be directly breastfed in mild cases, or nasally fed in severe cases, with intravenous rehydration to ensure nutritional supply if feeding is not possible. Newborns recovering from meningitis should be actively trained in various functions to reduce or mitigate sequelae. Parents need to pay attention to the room to open windows and ventilate frequently, and avoid taking the newborn to crowded places to reduce the risk of infection.