Pain under the big toe can be caused by toe nerve inflammation and tumor, bunion tumor infection, joint inflammation, trauma, etc. General, medication, physical and surgical treatments are available. 1. Toe neuritis and tumor: When the toe nerve of the big toe is inflamed or has a tumor, it can cause pain at the bottom of the big toe. It can be treated with localized microwave and far-infrared ray physiotherapy, as well as the application of nutritive nerve drugs such as methylcobalamin and analgesic drugs such as celecoxib as prescribed by the doctor, and surgical treatment is required for serious toe neuroma. 2. Bunion tumor infection: Tuberculosis, bacterial infection and tumor in the soft tissue and joints of the bunion can cause local pain, which can be treated with anti-tuberculosis drugs such as isoniazid, rifampicin and other anti-infective drugs such as cephalexin under the guidance of the doctor after clarification of the condition, and tumors need to be treated according to the conditions of the disease. 3. Joint inflammation: Rheumatoid arthritis and gouty arthritis at the big toe can cause localized pain, which needs to be clearly diagnosed and treated, and can be treated with anti-rheumatic drugs such as methotrexate and leflunomide, as well as uric acid-lowering drugs such as febutazole and allopurinol, according to the instructions of the doctor. 4. Trauma: Chronic strain injury at the big toe, or bone and soft tissue injury caused by trauma, can cause local pain symptoms. It is necessary to pay attention to the affected area to brake and rest, can be used externally flurbiprofen ester paste analgesic treatment, can be prescribed oral ibuprofen analgesic treatment, oral panax ginseng tablets to activate blood circulation and eliminate blood stasis treatment, and serious injuries need surgical treatment. If the injury is serious, surgery is needed. When the pain underneath the big toe is severe, you should consult a doctor in a timely manner, and under the guidance of a specialized doctor, you should actively carry out the appropriate treatment, which will help to alleviate the uncomfortable symptoms as soon as possible.