Antihypertensive drugs can be taken together with diuretic drugs, the efficacy of the two drugs will not affect each other and can promote each other to help the body lower blood pressure and diuretic. Commonly used antihypertensive drugs are Irbesartan tablets, nifedipine tablets, metoprolol extended-release tablets, etc. Commonly used diuretic drugs are hydrochlorothiazide tablets, furosemide tablets, spironolactone tablets, etc., the two drugs are taken at the same time, the efficacy of the drug will not be affected, and the long-term use of antihypertensive drugs will be the situation of the lower limbs of the swelling, the use of diuretic drugs can be effective in alleviating the swelling. But there are some antihypertensive drugs itself will contain diuretic ingredients, and some drugs may lead to electrolyte abnormalities in the body, different diuretics have different effects on the electrolyte, if the two drugs with unreasonable will make electrolyte significant abnormalities, therefore, in the choice of diuretic drugs, should be in the doctor’s advice and guidance of the rational use of regular observation of the body’s blood pressure, electrolyte levels. Should be under the guidance of the doctor to choose drugs, if the body produces other adverse reactions, should go to the hospital in time to check, symptomatic treatment, to avoid serious effects on the body.