White spots appearing at the corners of the mouth, in most cases, may be localized white furfuraceous rash, also known as simple furfuraceous rash, usually this kind of white spots do not need to do special treatment, and most of them can be healed by themselves. If some simple chaff rash can not be cured for a long time, you can use 5% sulfur ointment topical application, you can also use vitamin B6 cream topical application. If the border is clearer, and a long time does not subside, there is no obvious scaly symptoms, it may be vitiligo, for this case, you can use topical glucocorticoid hormones, such as halomethasone cream and so on. If the diagnosis is vitiligo, you need to apply topical Vialu liquid for treatment. After all, vitiligo treatment is not an overnight thing, so it needs a long time comprehensive treatment. If the white spots are due to local inflammation after the loss of pigment, usually do not need treatment, let it repair itself can be.