To investigate the multiple factors affecting relapse of schizophrenia. The authors analyzed the causes of relapse in 222 patients with schizophrenia with onset of less than 2 years who were followed up annually within 5 years of discharge. The results showed a 2-year relapse rate of 45.5% and a 5-year relapse rate of 78,3%. Relapse was significantly related to age of onset, personality, genetics, literacy, form of onset, compliance and social and family support. It is concluded that relapse of schizophrenia is influenced by multiple factors and effective measures should be taken for early intervention. DISCUSSION: The factors affecting relapse in schizophrenia are very complex. Factors related to genetics, personality, literacy, form of initiation, maintenance treatment and social and family interventions can all influence relapse. This may be due to the fact that acute onset patients often have more prominent symptoms and are more dangerous to society and families, so they are easily noticed by their families and receive medical intervention earlier. 2, personality, the recurrence rate of inwardly inclined patients in this group is much higher than that of externally inclined patients, which is consistent with the assertion that inwardly inclined patients have a worse prognosis and are prone to recurrence. 3, genetic history, this data shows that those with genetic history have poor healing and high recurrence rate. The higher the level of education and intelligence, the higher the level of pre-morbid occupational functioning, the better the prognosis and the lower the relapse rate.5 Compliance, improving the compliance of schizophrenia patients with maintenance treatment can reduce the relapse rate of the disease.6 Social support and family intervention, if social and family support is inadequate and cannot effectively relieve various stress, excessive blaming of the patient, excessive inclusion and excessive emotional involvement can affect the patient’s condition and lead to an increased relapse rate. In conclusion, to reduce the relapse rate of schizophrenia and maximize recovery, a set of reasonable prevention, treatment, and recovery strategies should be provided to patients and their families. The first priority is to improve the patient’s compliance with medication. Only by adhering to reasonable long-term medication, together with effective social and family mental health services, can we achieve the goal of recovery.