Leg pain caused by cerebral infarction can be effectively relieved or even completely recovered after active treatment in some cases, while it is difficult for some patients to return to normal completely. Cerebral infarction is mainly caused by atherosclerosis of large arteries, cardiogenic embolism, occlusion of small arteries, cerebral arterial vascular occlusion and other factors, and the symptoms manifested as headache and dizziness, hemiplegia, aphasia, limb sensory abnormalities and so on. The cause of leg pain after cerebral infarction may be contracture caused by increased muscle tone, which can be treated with medicines such as baclofen; leg pain caused by deep vein thrombosis can be treated with anticoagulation or interventional thrombectomy. Leg pain occurred by thalamic infarction, the patient may feel severe pain, in addition to give the conventional treatment of cerebral infarction of drugs, such as aspirin, etc., but also can be given antiepileptic drugs, such as carbamazepine, etc. for treatment. Some patients may have post-stroke affective disorder, due to anxiety and depression, and may also feel leg pain, which belongs to emotional psychological factors. In addition to anti-anxiety and antidepressant drugs such as buspirone and fluoxetine, psychological counseling should be given to the patients. Leg pain caused by cerebral infarction itself, with the recovery of cerebral infarction and recovery, usually easy to leave sequelae, it is difficult to completely return to normal. On the other hand, leg pain caused by deep vein thrombosis or psychological factors can be effectively relieved or even completely returned to normal after the triggers are removed. If patients have leg pain caused by cerebral infarction, they should consult their doctors in time and take targeted treatment under the doctor’s guidance.