Heterozygous for a-sea gene deletion is thalassemia. Heterozygosity for this gene is the basis for a definitive diagnosis of thalassemia in genetic testing. Patients with alpha-thalassemia can be diagnosed with mild alpha-thalassemia, which does not produce obvious symptoms and does not require any medication until symptoms appear, although patients should have regular blood tests and ferritin levels checked. When the patient develops anemia, it is mainly due to a disorder in the synthesis of the bead protein, which is necessary for the synthesis of hemoglobin, and this leads to microcytic hypochromic anemia. The disease has hereditary properties and patients should have prenatal counseling when having children.