Sulfonylureas, dipeptidyl peptidase inhibitors, thiazolidinediones, and so on, are hypoglycemic agents with little gastric stimulation. 1. Sulfonylureas: commonly used hypoglycemic drugs include gliclazide, glimepiride, glipizide, etc. Hypoglycemia and weight gain are easy to occur, and individual patients may have skin allergic reaction and leukopenia. 2. Dipeptidyl peptidase inhibitors: commonly used hypoglycemic drugs include selegiline, ligustine, etc.; common adverse reactions include allergy, elevation of liver enzymes, upper respiratory tract infections and pancreatitis. 3. Thiazolidinediones: commonly used hypoglycemic drugs are pioglitazone, rosiglitazone, etc.; it may increase the risk of heart failure, and is prohibited for patients with severe cardiac insufficiency. When taking these hypoglycemic drugs, you need to take them under the guidance of a doctor.