Patients with knee muscle pain, commonly due to osteoarthritis, peripheral muscle trauma, as follows: first, osteoarthritis: osteoarthritis of the knee joint patients, there will be a serious peripheral muscle atrophy, the patient is prone to strain after weight-bearing walks, which produces symptoms of pain in the knee joint peripheral muscle pain, accompanied by weakness of the knee joint performance. Second, the surrounding muscle trauma: trauma to the muscles around the knee joint, such as quadriceps, calf triceps, in the process of strenuous exercise, acute injury can occur, the muscles will have obvious edema, pain, activity limitation, and even the knee can not short-term weight-bearing, the movement is forced to stop, after the cold treatment can make the symptom get relief. The pain in the muscles around the knee joint should be diagnosed early and the cause of the disease should be clearly defined, and according to the different causes of the disease to choose the appropriate treatment methods, in order to make the clinical symptoms be relieved. In normal life, attention should be paid to avoid serious muscle atrophy and muscle trauma to prevent the recurrence of symptoms.