Which blood sugar is more reliable?

  Since different parts and different types of blood contain different components, which more or less interfere with the existing testing methods and affect the final blood glucose test results, how do the accuracy of the various types of blood test results rank?  Arterial blood > arterial capillary blood > venous capillary blood > venous blood. The specimen for measuring blood glucose is most convenient and the measured results are most reliable with plasma. In general, the glucose concentration of whole blood is 10%-15% lower than that of plasma (due to the volume occupied by blood cells), and there is no difference between the measured values of capillary blood samples and venous blood samples when fasting, but for the blood samples 1 hour after meal, the plasma glucose level of the two can differ by 2.27±0.66 mmol/ L. Since peripheral blood is whole blood, it is lower than that of plasma and serum, but many blood glucose meters now correct the measured results to plasma level. As for serum, it is lower than plasma because it takes time to form serum and RBCs consume blood glucose. The water content of whole blood is different from that of plasma, 81% and 93% respectively, and the water solubility of glucose is greater, so the measurement with whole blood will be lower than that of plasma by about 12% to 15%. The main difference between plasma and serum is that serum does not contain fibrinogen, and there is no significant difference in the concentration of blood glucose between the two.  If plasma is used, there are strict requirements for the selection of anticoagulant, because anticoagulant often interferes with the determination results, and some of them also have great influence on the enzyme reagents, so it is most suitable to use serum to determine blood glucose. When in the same environmental conditions and physiological conditions, the blood glucose concentration should be: serum ≥ plasma > peripheral blood.