The impact of having one less kidney in men mainly depends on the cause of the missing kidney, and the functional status of the opposite kidney, e.g. the life of isolated kidney and kidney transplant patients with normal function of the opposite kidney after surgery is usually normal. However, if the other kidney also has problems, it may have a greater impact on the patient’s life and health. Generally speaking, men with one less kidney do not experience any significant impact on their lives. A healthy kidney is enough to maintain the normal life of an adult male. In the process of physical examination, there will be people who have one kidney detected by chance, which is clinically called an isolated kidney, and this kind of people will not have obvious abnormality, and one kidney will have a compensatory role in providing detoxification and drainage required by the human body. Uremic patients after kidney transplantation, the patient’s opposite side of the kidney function is normal, 3 months after the operation, the opposite side of the kidney can take over the work of the original 2 kidneys, at this time the patient, will not be troubled by kidney function, and do not need to undergo dialysis and other treatments. If the kidney function of the opposite side is abnormal, both sides of the male patient’s kidneys were abnormal before the surgery, and one kidney is missing after the surgery, the opposite side of the relatively good kidneys can’t fully compensate for it, at this time, we should mainly use nephrology to protect the kidneys, and pay attention to the maintenance of the kidneys. If the kidney on the opposite side has bigger problems or cannot compensate for the loss and develops uremia, then the patient may need dialysis treatment or even a kidney transplant. It is recommended that these patients go to the hospital in time for relevant examinations to clarify the cause and standardize the treatment under the guidance of the doctor.