Blood creatinine 220μmol / L with diarrhea need to identify the cause, common causes include drug-induced, infectious diarrhea and so on. Common drugs such as renal failure, urethane, etc. can lead to diarrhea, then need to stop using the relevant drugs, observe the condition; infectious diarrhea can be oral montelukast, levofloxacin and so on. The normal range of blood creatinine is 53~106μmol/L for men and 44~97μmol/L for women, the reference value is different in different hospitals, please follow the local hospital. When elevated blood creatinine level is accompanied by diarrhea, the cause of elevated blood creatinine level should be clarified, and common causes include drug-induced (e.g. nephronin, urethane, etc.), at this time, it is necessary to discontinue the relevant drugs, and observe the changes of the condition closely. At the same time can be given to stop diarrhea, rehydration and other drug therapy, drugs can choose montelukast. If it is caused by infection, it may be accompanied by abdominal pain, fever, stool routine examination of white blood cells, at this time, we need to stop diarrhea, rehydration at the same time, choose antibiotic treatment, optional drugs are bifidobacteria triple live bacteria, levofloxacin and so on. Because a large amount of diarrhea loss of water, can cause shock, renal function deterioration and other conditions, causing blood creatinine level further increase, need to closely monitor vital signs and blood creatinine. Patients should be instructed to avoid cold diet, expired food, etc. to avoid diarrhea, so as not to aggravate the burden on the kidneys. Meanwhile, the cause of elevated creatinine should be identified and creatinine level should be controlled. For patients with elevated creatinine and diarrhea, it is recommended to go to regular hospitals in time to find out the cause of elevated creatinine and follow the doctor’s instructions for standardized treatment.