Yawning chest pain, in general, may be intercostal neuralgia, pleurisy, costochondritis, muscle injury and other causes. 1. Intercostal neuralgia: Intercostal neuralgia refers to the pain symptoms in the intercostal innervated area produced by the thoracic nerve root or intercostal nerve due to different damages. The pain is tingling or burning, paroxysmal or persistent, mostly in the chest or abdomen in a band-like distribution, and the chest pain will be aggravated when yawning. 2. Pleurisy: generally caused by infection, injury, tumor and other factors. With pleurisy, the chest will expand when yawning, and the expansion of the chest will lead to the increase of friction between the pleura of the dirty layer and the pleura of the wall layer, thus causing chest pain. 3. Costochondritis: Costochondritis can be secondary to viral infection, trauma, chronic strain of the ligaments of the thoracic and rib joints, etc. Depending on the cause of the disease, the manifestation of the symptoms are not the same, but all of them can be manifested as pain in the anterior part of the chest and pain on pressure, which can be radiated to the cervical and thoracic area, the back, and the armpits. Some of the costochondritis may have chest tightness, aggravated by coughing, yawning and deep breathing. 4. Muscle injury: excessive exertion of the chest muscles of the patient may lead to muscle injury, and the patient’s ribs expand and lift up when yawning, pulling the damaged muscles, which may also lead to chest pain. Yawning chest pain causes more reasons, should go to the hospital in a timely manner to check, clear cause, under the guidance of the doctor for appropriate treatment.