Delayed-onset dyskinesia clinically manifests mainly rhythmic stereotypic repetitive involuntary movements. Tardive dyskinesia (TD), also known as delayed hyperactivity disorder and persistent dyskinesia, is induced by antipsychotic medication as a persistent stereotyped repetitive involuntary movement. It is the most severe and problematic extrapyramidal reaction caused by antipsychotic medication, with a fairly high incidence. It is most commonly caused by phenothiazines and butyrophenones. The incidence of oral generic antipsychotics is 20% to 40%, and the incidence with long-acting antipsychotics is about 50%. Crane (1968) first suggested that it is the most serious and problematic extrapyramidal reaction caused by antipsychotic treatment, with a fairly high incidence. The most common are caused by phenothiazines and butyrophenones. The incidence of oral generic antipsychotics is 20% to 40%, and the incidence with long-acting antipsychotics is about 50%. The cause of rhythmic repetitive involuntary movements: mainly seen in patients taking high doses of antipsychotics for a long time (more than 1 to 2 years), mostly in elderly patients, especially women, with organic brain lesions, most commonly caused by phenothiazines and butyrophenones, fluphenazine trifluoperazine and haloperidol and other fluorine-containing antipsychotics are common, and most likely to occur after dose reduction or discontinuation. Discontinuation of antipsychotics can make tardive dyskinesia more pronounced, while increasing the dose of antipsychotics can temporarily reduce tardive dyskinesia. The incidence varies by drug type, dose, dosing period, and individual differences. The incidence of oral generic antipsychotics is 20% to 40%, and the incidence of long-acting antipsychotics is about 50%. It is generally believed that the latter is caused by hypersensitivity in response to long-term medication blockade of striatal dopaminergic receptors and may also be related to impaired basal ganglia GABA function. Associated factors include: 1, age and gender factors: the elderly are prone to occur, not easily recovered, and more women than men. 2. Patients with brain lesions are prone to the use of antipsychotics, and patients with negative symptomatic schizophrenia have an early age of onset and high incidence of TD. 3, drug factors: drug dose and duration of treatment are related to the occurrence of TD, mostly seen in patients with Parkinson’s syndrome occurring early in treatment.