After peritoneal dialysis, creatinine still can’t come down mostly due to excessive creatinine production, such as combined infection; or because creatinine is excreted too little, which is mostly due to the patient’s peritoneal function may be low transit, or dialysis is not sufficient. Patients can control the infection according to their own situation, or adjust the number of peritoneal dialysis, change to hemodialysis and other methods of treatment. Peritoneal dialysis utilizes the patient’s own peritoneum as a semi-permeable membrane, and through the infusion of dialysis fluid into the peritoneal cavity, solute exchange between blood and dialysis fluid is achieved to remove metabolic wastes from the blood, maintain electrolyte and acid-base balance, and at the same time, remove excess fluid. For small molecule toxins (such as creatinine, urea nitrogen), peritoneal dialysis is poorer than hemodialysis clearance, so many peritoneal dialysis patients, after dialysis, review blood creatinine is still high. Of course, there are many other reasons why peritoneal dialysis patients’ creatinine still can’t come down, such as excessive creatinine production (combined with infection, strenuous exercise, eating a lot of meat, etc.); creatinine discharge is too small, such as peritoneal sclerosis, the peritoneal function belongs to the low average or low transit, the dialysis dosage or the number of times is not enough, which results in insufficient dialysis and so on, which all lead to the creatinine not to come down. To deal with the above situations, we can follow the doctor’s instructions to fight infection (such as amoxicillin), pay attention to rest, eat a light diet or change to hemodialysis, increase the dose or frequency of dialysis, etc. to remove the excess creatinine. If the creatinine still can’t come down after peritoneal dialysis, the patient should go to the hospital in time and choose the appropriate method of treatment.