Asthma is a common disease in the elderly and is divided into true asthma and pseudo-asthma. Most clinical asthma is pseudo-asthma, caused by gastroesophageal reflux disease, which many people do not recognize. “Gastroesophageal reflux disease (GERD) is a disease in which the abnormal reflux of gastric contents into the esophagus causes symptoms and complications of asthma. The clinical manifestations are diverse and complex, including esophageal symptoms, extraesophageal symptoms and complications. Typical symptoms are esophageal symptoms: acid reflux, regurgitation, belching and reflux irritation such as heartburn, chest pain and dysphagia. There is also a group of extra-esophageal symptoms, such as asthma, chronic cough, and chronic laryngitis. Some patients do not have obvious typical esophageal symptoms and directly present with asthma and cough, and this part is the most misdiagnosed population. This group of patients is usually seen in the respiratory department for a long time, when in fact the cause of his disease is caused by GERD. In addition the prolonged condition can lead to complications such as reflux esophagitis, esophageal bleeding, esophageal stricture, Barrett’s esophagus and esophageal adenocarcinoma. The main cause of GERD is the relaxation of the lower esophagus. There is a high-pressure zone at the junction of the esophagus and stomach called the lower esophageal sphincter, which causes the reflux of stomach contents into the esophagus, pharynx and trachea, resulting in various symptoms, and some patients have a hiatal hernia. This disease was originally a disease of the middle-aged and elderly, and its incidence increases significantly after the age of 45 to 50, which is related to the physiological changes of the elderly, for example, the elderly are usually accompanied by esophageal hiatal hernia, which often develops along with GERD; in addition, the elderly are also more fat and have high abdominal pressure, which easily leads to the occurrence of GERD. However, recently we also found many young people, 20, 30, 30, 40 people also. This part of patients may be related to bad habits such as drinking alcohol, frequent consumption of carbonated beverages, long-term smoking, and full meals before bedtime. Nowadays, internal medicine treatment is mainly acid suppression treatment, supplemented by some gastric power drugs, so that the stomach contents go down faster and less reflux will occur. However, medication does not control reflux, but only serves to reduce the damage caused by the refluxed material, and many patients have recurrent symptoms after stopping the medication. The Nissen fundoplication for GERD was invented as early as 1936, using the principle of folding and suturing the tissue of the stomach wall itself to tighten the lower esophageal sphincter. However, at that time, this procedure usually required an open chest or abdomen, which was more invasive. With the development of minimally invasive laparoscopic technology, laparoscopic fundoplication began to be used in clinical practice in the 1990s, and became rapidly popular because of the advantages of simple operation, low pain, safety and effectiveness. Many scholars refer to laparoscopic fundoplication as the “gold standard” for the treatment of GERD. The procedure is performed with only 4-5 small 0.5-1.0 cm wounds in the patient’s abdomen, and the patient can eat and resume daily activities the day after surgery and be discharged from the hospital in 3-5 days. Laparoscopic anti-reflux surgery is the most effective, proven and safe treatment for GERD than drug therapy.