On how important the skull is, it must be clear that it is the hard protective shell of the brain, the commander-in-chief of the human body, and if there is an accidental defect in the skull, then the next problem is more serious. In neurosurgery, there are many patients with cranial defects, most of them have cranial defects due to craniotomy or decompression surgery, and some of them even remain in a coma after surgery. For the problem of cranial defects, the clinical recommendation is that the defect area more than 3cm and meet the surgical indications of the patient to do as soon as possible cranial repair surgery, that cranial repair can promote brain wakefulness? Many patients’ families have such a question, in fact, this is not certain, because the patient coma is more complex, coma factors are different, cranial repair hand whether you can wake up is no way to guarantee. But one thing is certain, long-term skull defect is not conducive to the patient’s wakefulness, because the skull defect will lead to the patient’s intracranial pressure and intracranial environment changes, will cause cerebral blood and cerebrospinal fluid circulation disorders, but also damage to the cerebral neural function and so on, all of these kinds of patients will be more physically stressful. Therefore, for patients who are unconscious and have skull defects, it makes sense to arrange for skull repair surgery at the right time, and to a certain extent, it will help the patient’s brain to wake up. However, to do skull repair surgery to go to a regular hospital, but also have to choose a good repair material, by the experience and technology of the better doctors to treat, so that the operation is more successful.