Whether a positive HPV33 infection is serious or not depends on the specific situation. Simple positivity is not serious, while the presence of cervical lesions is more serious and requires appropriate treatment. 1. Not serious: HPV33 infection is mostly a transient infection, and most of the infected people can achieve natural conversion through improving their living habits and strengthening their physical fitness, and some of them can be converted through medication (e.g., thymopeptide, transfer factor, etc.) to achieve conversion, so simple HPV33 infection is not serious. 2. Serious: HPV33 is a high-risk type, long-term infection can lead to cervical cancer and other negative prognosis, HPV33 infection should follow the doctor’s instructions to carry out TCT (Liquid-based Thin Layer Cytology) examination, and if there is any abnormality, further colposcopy biopsy is needed. If precancerous lesions are found, they are more serious and require prompt treatment (e.g., cervical conization, total hysterectomy, etc.) to avoid progression to advanced cervical cancer. To summarize, HPV33 positive is not serious in most cases and there is no need to be too anxious. However, a very small number of people with long-term infection can lead to cervical cancer, so HPV33 positive need to follow the doctor’s advice for relevant examination and treatment.