The symptoms of nodular disease include the following: 1. Skin nodular erythema may appear, and some patients may develop hepatomegaly or splenomegaly. 2. Eye damage may occur, such as vision loss, eye dryness, pain, and congestion of the ciliary body of the eye. 3. If the patient’s central nervous system has been invaded, there is a possibility of brain nerve loss, convulsions, paralysis and intracranial hypertension. 5, there may also be fever, loss of appetite, weight loss and weakness.