Swelling of palms may be a precursor of cancer, or it may be caused by other diseases such as skin allergy and osteoporosis. 1. Cancer: Cancer is a kind of tumor, malignant tumor originated from epithelial tissue. It can occur in any part of human body. Common clinical symptoms include swelling, pain, bleeding and enlarged lymph nodes, etc. Therefore, when patients’ palms appear to be swollen, it may be a precursor of cancer. 2. Allergic dermatosis: Allergic dermatosis is a common skin disease caused by stimulation of animal, plant and chemical allergens. When the patient’s palms come into contact with allergens, it will lead to symptoms such as swelling and tingling of palms. 3. Osteoporosis: Osteoporosis is a metabolic bone disease, when the patient’s small joints are overactive, it will make the local synovial tissues of small joints produce edema, which can be felt in the palm of the hand, accompanied by localized pressure and pain. It is recommended that patients with symptoms of swelling in the palm of the hand should go to the hospital for examination to determine the cause of the disease, and should not make unauthorized judgments, resulting in delays in the condition.