A brain hemorrhage is a rupture of a blood vessel located inside the brain parenchyma, and blood enters directly inside the brain parenchyma to form a hematoma, compressing brain cells and causing them to become ischemic and die. If a patient has a cerebral hemorrhage and the amount of bleeding reaches 80 ml, it will cause a large number of brain cells to become ischemic and die, thus causing edema. At this point, the patient’s condition is more serious, and he or she may develop coma, brain herniation, or even die within a few hours. Because a brain hemorrhage of 80 ml is a massive brain hemorrhage, it is a more serious and lethal brain hemorrhage. For patients with brain hemorrhage of 80 ml, rescue treatment is needed as soon as possible to actively dehydrate and lower the cranial pressure to prevent brain herniation from occurring. If the patient is eligible for surgery, surgical treatment of cranial hematoma removal should be taken in a timely manner, and if necessary, bone flap decompression or partial brain tissue removal can be performed to reduce the incidence of cerebral edema. If patients are not eligible for surgery, they cannot be treated surgically and can be treated conservatively, which mainly includes bed rest, applying dehydrating drugs to reduce intracranial pressure and applying hemostatic drugs as prescribed by the doctor. Patients with high blood pressure should be controlled with antihypertensive drugs, and cephalosporin or penicillin drugs should be applied to prevent infection. Most patients with brain hemorrhage of 80 ml will have impaired consciousness, so special attention should be paid to keeping the patient’s airway open during care. Patients can tilt their heads to the side when vomiting to prevent vomit from being accidentally aspirated and causing aspiration pneumonia or asphyxia.