The survival period of advanced cholangiocarcinoma with ascites is relatively short, and the survival rate of 5 years is about 9%, which should be analyzed in the light of individual situation as well as the progress of the disease. Most cholangiocarcinoma patients are already in advanced stage once diagnosed, with ascites as well as jaundice. The condition of these patients is more serious and the degree of malignancy is relatively high, and they have already missed the time for surgery, with a 5-year survival rate of about 9%. At present, if advanced cholangiocarcinoma with ascites is detected, radiotherapy should be adopted as soon as possible to inhibit the cancer cells, and the main treatment principle is to prolong the survival period and improve the quality of life. If ascites is deeper and accompanied by jaundice and loss of appetite, it is considered to be caused by bile duct obstruction, and the symptoms should be improved through biliary stenting, parenteral nutrition or peritoneal puncture to drain ascites. Patients with advanced cholangiocarcinoma ascites should have confidence in facing the disease and avoid excessive anxiety and fear. If the present condition is complicated and the symptoms are more serious, try to consult and treat systematically in the hospital.