Adapalene is not recommended for long term use as it can irritate the skin or develop resistance over time. Adapalene belongs to the group of medications known as retinoids, and it is mainly effective against common acne. The drug is slow acting and may be used for a longer period of time, but it should be discontinued when the condition is cured and should not be used for a long period of time. Prolonged application may produce adverse reactions such as redness, burning sensation and dryness of the skin. In addition, long-term use can produce drug resistance. Adapalene should be used under the supervision of a physician, and regular reviews are required during use to assess the effectiveness of treatment, and sun protection should be observed during use of the drug. If adverse reactions occur during the use of the drug, such as skin redness, swelling, itching, etc. to consult a doctor, if necessary, stop the drug. In addition, infants and pregnant women are not recommended.