A 59-year-old patient, Shuang, has been suffering from immune thrombocytopenic purpura for 3 years, and has been taking hormones for a long time due to treatment needs. In June, after a multidisciplinary consultation and thorough preoperative preparation, Shuang underwent splenectomy in our hospital. A few days ago, the patient came to the hospital for a recheck of his platelets in the normal range, and his steroidal diabetes, which was caused by long-term hormone use, was cured by itself after he stopped using hormones. The family is very satisfied with the treatment result. In the past six months, the Department of General Surgery has successfully performed splenectomy for nearly 10 such patients and patients with unexplained splenomegaly with fever. All patients recovered successfully without complications and stopped taking hormones while their diabetes mellitus resolved spontaneously. Idiopathic thrombocytopenic purpura (ITP) is also known as primary or immune thrombocytopenic purpura. This disease is associated with autoimmunity, where platelets are accompanied by an antibody that shortens their life span and is destroyed in the spleen and liver. The acute form is most often seen in children and is often preceded by a history of infection. Petechiae appear on the skin, and the mucous membranes of the gums, mouth, and nasal cavity bleed. The chronic type is most often seen in young women, and the bleeding is persistent or recurrent. Some women mainly present with excessive menstruation. The platelet count is often below 50×109/L, and the spleen is usually mildly enlarged. In this disease, fresh blood should be transfused and adrenocorticosteroids should be applied when bleeding is significant. Splenectomy is indicated for: ① Severe uncontrollable and life-threatening bleeding, especially those with the possibility of intracranial hemorrhage. ②After adrenocorticotropic hormone treatment for more than 6 months is ineffective; or the remission period after treatment is short, still repeatedly recurring patients. ③High-dose hormone therapy can temporarily relieve the symptoms, but in view of the side effects of hormone therapy, and the maintenance amount needs to be more than 30mg/d. ④The hormone application is contraindicated. After splenectomy, about 80% of patients get satisfactory results, and the need for glucocorticoids can also be reduced in those who are ineffective. Postoperative bleeding stops rapidly and platelet count rises rapidly within a few days.