The use of alcohol and the consumption of alcohol after medication may have a greater impact on the effectiveness of certain drugs, or even bring serious harm. Today to give you a summary! 1. antipyretic and analgesic drugs Alcohol can cause a large secretion of serum gastrin, antipyretic and analgesic drugs such as aspirin, acetaminophen, etc., can also increase the secretion of gastrin in the serum. The combination of the two may lead to a sharp increase in the concentration of gastrin secretion and a large secretion of gastric acid, which may destroy the gastric mucosal barrier and damage the submucosal blood vessels, causing the risk of gastric bleeding. It is also worth mentioning that some healthy people who drink alcohol can get severe headaches, and if they take painkillers on their own, they are also likely to induce gastrointestinal bleeding. 2. sedative intoxicant Ethanol has the effect of inhibiting the central nervous system, and the effect is proportional to the amount of alcohol consumed. Phenobarbital, chlordiazepoxide, chloral hydrate and other central nervous system depressants can cause a deeper inhibition of the central nervous system, causing drowsiness in mild cases and coma in severe cases, and even death due to central nervous system paralysis. 3. anti-allergic drugs such as Benadryl, chlorpheniramine, dechlorperazine, cycloheximide, etc.. The consequences of taking these drugs with alcohol are similar to those of sedative-hypnotics. 4. antibacterial drugs such as cephalosporins, furosemide, metronidazole and other drugs, drinking alcohol can inhibit the metabolism of ethanol, causing a “disulfiram-like reaction”, headache, dizziness, nausea, vomiting, panic, chest tightness, dyspnea, decreased blood pressure and a series of symptoms. Alcohol has the effect of inhibiting the absorption of sugar, after taking the hypoglycemic drug glibenclamide, metformin or insulin injection, it will cause a rapid drop in blood sugar, dizziness, panic, cold sweat, shaking hands and other hypoglycemic reactions, serious cases can cause hypoglycemic coma, if the rescue is not timely, life-threatening. It is worth warning that such hypoglycemic symptoms, often masked by drunkenness reaction, are not easily distinguished from drunkenness, so much so that they lead to severe and persistent hypoglycemia, causing irreversible damage to brain tissue and even causing death. During the consumption of sulfonylurea hypoglycemic drugs, ethanol acts as an enzyme inducer and can promote the metabolism of sulfonylurea drugs and shorten their half-life significantly, thus weakening their hypoglycemic effect. In addition, the consumption of alcohol and other biguanide hypoglycemic drugs may also cause lactic acidosis. 6. antiepileptic drugs such as phenytoin sodium, such as drinking alcohol during the drug can reduce the efficacy, or even induce seizures. 7. anti-angina drugs such as isosorbide nitrate, nitroglycerin and nifedipine and other vasodilators, drinking alcohol when taking, can cause excessive expansion of blood vessels, resulting in severe headaches, a sharp drop in blood pressure and even shock. 8. antihypertensive drugs Alcohol has the effect of dilating blood vessels, causing sympathetic nerves and vasomotor centers and weakening myocardial contractility. If you take antihypertensive drugs (compound rifampicin, hydrazinoprazine, benidipine, dibazol, tachyphylaxis, diuretic acid, etc.) after drinking, the drop makes small blood vessels more dilated, blood volume is further reduced, blood pressure drops suddenly, and postural hypotension or fainting occurs. 9. hemostatic drugs and anticoagulants Alcohol can inhibit clotting factors, counteract hemostatic drugs, so that the role of hemostatic drugs is greatly reduced. Alcohol can affect the competition of anticoagulants such as coumarin for liver enzymes, thus enhancing their anticoagulant effect and leading to a shorter half-life of the drug, affecting its efficacy. 10. diuretics Diuretics such as dihydrochlorothiazide, tachyphylaxis, and ambrisentan can lower blood pressure through urination, and once alcohol is consumed, the vasodilating effect of alcohol can cause hypotension and dizziness reactions, and even upright deficiency. 11. antidepressants such as promethazine and doxepin, if consumed during the drug, can produce sedative effects, thereby reducing the effectiveness of the drug, but also lead to the deposition of fat in the liver, so that the small intestine peristalsis will be weak, and even intestinal paralysis. 12. anti-tuberculosis drugs The oxidation process of alcohol in the body can produce a large number of free radicals, and the increase of free radicals can damage liver cells. Isoniazid, rifampin and other anti-tuberculosis drugs can increase the hepatotoxicity of alcohol, causing jaundice and liver decompensation.