There are many causes of yellow rice-like substance extruding from the face, which may belong to cornu rashes, epidermoid cysts, acne vulgaris, etc. It is necessary to choose medication or surgical treatment according to different diseases. 1. Corns: Often called fat grains, they are tiny subepidermal keratinized cysts originating from the sebaceous gland units of hair follicles and can be seen at any age. They usually appear as yellow granular pimples, and when squeezed, a yellow rice-like substance appears. 2. Epidermoid cysts: These are usually skin-colored or gray cysts with openings in the center of some of them, which can be extruded as yellow granular material or soya bean dregs, and can be treated by surgical excision. 3. Acne vulgaris: Acne vulgaris is a chronic inflammatory disease of the hair follicles, which occurs in teenagers and damages the sebaceous glands of the hair follicles, and pimples, nodules and cysts appear on the facial skin. Some infected acne can extrude yellow granular material, which can be treated with topical antibiotics such as benzoyl peroxide gel or oral minocycline under the advice of a doctor. There may be other reasons for the yellow granular material extruding from the face. Avoid squeezing the facial skin on a daily basis and consult a doctor for standardized treatment under the guidance of the doctor.