Headache and vomiting during physiological period is considered to be migraine during menstruation, usually such patients will have pain every menstruation period, and there can be a family genetic history of the disease, for this kind of migraine, estrogen replacement therapy can be given. Estrogen replacement therapy can be given to these migraines. Migraines during menstruation are mainly caused by a decrease in estrogen secretion during menstruation, which leads to vasodilation and contraction dysfunction, and then migraines appear. Alternative treatment is to give the patient estrogen treatment, but also can be carried out with TCM herbal medicine identification treatment, can also be combined with acupuncture, physiotherapy, improve the menstrual migraine, can also give the patient some medications for migraine, such as ergotamine preparation, but do not recommend that the patient long-term oral intake. If the patient’s menstrual headache is more serious, also consider the Triptans type of painkillers.