Patients who have had shingles do not acquire lifelong immunity and can get shingles repeatedly when they are immunocompromised. Herpes zoster is a viral disease caused by varicella-zoster virus infection and is characterized by unilateral erythema and clusters of blisters on the skin with significant pain. Patients are usually associated with low immunity, poor sleep, and fatigue. Patients with diabetes mellitus and AIDS are prone to recurrent attacks. The treatment is a combination of antiviral, nerve nutrition, and physical therapy as necessary.