Atrial fibrillation is not recommended to take quick-acting cardiac pills, because quick-acting cardiac pills are drugs that move Qi and blood, remove blood stasis and relieve pain, which can increase coronary blood flow. This drug can relieve angina pectoris, i.e. myocardial ischemia, qi stagnation and blood stasis type coronary heart disease and angina pectoris treatment. Therefore, quick-acting heart pills may have a therapeutic effect on patients with atrial fibrillation combined with coronary artery disease. However, in patients with atrial fibrillation alone, the therapeutic effect is very limited and does not relieve the symptoms. Therefore, patients with atrial fibrillation should first clarify the cause of the disease and further target treatment according to the cause. Patients with atrial fibrillation who have coronary artery disease can take quick-acting heart pills to relieve angina symptoms when their heart rate is particularly fast, but they do not have much therapeutic effect on atrial fibrillation. The primary treatment for patients with atrial fibrillation includes adequate anticoagulation, stroke prevention, ventricular rate control, and treatment to maintain sinus rhythm. Maintenance of sinus rhythm and anticoagulation therapy is the mainstay in paroxysmal AF, and if persistent AF may be based on anticoagulation therapy for ventricular rate control. Therefore, it is not reasonable to treat atrial fibrillation with oral rapid-acting heart pills. Atrial fibrillation should be seen promptly to clarify the cause, while its targeted treatment.