Early super rejection is the biggest fear of bone marrow transplantation. Early super rejection reaction is more dangerous, even some patients have central nervous system rejection, and central nervous system involvement is life threatening. Intestinal rejection is characterized by bloody stools, mostly persistent, difficult to stop, patients with electrolyte disorders, protein loss, which can affect the life of the child. There is also hepatic rejection reaction, which can lead to liver failure, hepatic jaundice, elevated liver enzymes, should pay attention to hepatic rejection and intestinal rejection. The condition of rejection reaction is dangerous, with multiple organ involvement, and the success rate of resuscitation is very low, so it should be recognized and controlled at an early stage. If rejection reaction occurs, anti-rejection drug treatment should be strengthened to reduce the symptoms.