Causes of digitalis poisoning

Digitalis drugs are commonly used in clinical practice as positive inotropic drugs, such as digoxin and cetiran, and are mainly used for various acute and chronic heart failure or cardiac insufficiency. The dose of digitalis drugs does not correlate with the degree of intoxication, and some patients may develop digitalis toxicity even at low doses of treatment. The causes of digitalis toxicity in patients are: 1. The pharmacokinetic effect of digitalis in the body leads to drug aggregation resulting in toxicity, because the metabolism of digitalis in the body passes through the kidneys, if the patient’s kidney function is abnormal or the clearance of digitalis by the kidneys is reduced, it can lead to the increase of digitalis drug content in the serum resulting in toxicity. 2. The tolerance of the body to digitalis drugs is low, and with the growth of age or the past The heart muscle cells receive damage, low doses of drugs can lead to the body’s heart arrhythmia and other sub-toxic state.