Piperacillin/tazobactam are both antibiotics that can be used to treat gastroenteritis. 1. Piperacillin: a semi-synthetic penicillin with broad-spectrum antimicrobial effect for Escherichia coli, Escherichia coli, Klebsiella, hemolytic streptococcus, Streptococcus pneumoniae and so on have a certain antimicrobial effect, can be used for the treatment of gastroenteritis, but for those who are allergic to penicillin is contraindicated, the use of piperacillin in clinical practice may cause diarrhea, nausea, vomiting, skin rashes, headache and other adverse reactions. 2. Tazobactam: β-lactamase inhibitor, clinically used to inhibit the production of drug-resistant bacteria, but also has a certain antibacterial effect, penicillin, cephalosporins or β-lactamase inhibitor allergy is contraindicated, the clinical adverse reactions include urticaria, itching, nausea, vomiting, fever, etc., once the adverse reactions should be discontinued in a timely manner for treatment. Clinically, before using antibiotics, the causative organisms of the infection can be clarified through routine blood tests, bacterial culture and drug sensitivity tests, and then antibiotics can be used under the guidance of physicians for treatment.