Cranial defects often have headache, localized tenderness, irritability, restlessness and other manifestations; or fear of local collapse, pulsation. As a result of large cranial defects caused by the patient’s skull serious deformity, directly affecting the physiological balance of intracranial pressure, and because the atmospheric pressure directly through the defective area on the brain tissue, after a certain period of time is bound to lead to local brain atrophy, aggravate the symptoms of cerebral impairment. Therefore, patients with cranial damage should undergo repair surgery in a timely manner. Cranial repair surgery is not a very difficult operation in the field of neurosurgery, and the risk factor is not very high. However, the appropriateness of this type of surgery and the timing of skull repair should be determined on a patient-by-patient basis. For patients with open comminuted skull fractures with relatively clean wounds and no cranial hypertension, it is recommended that cranioplasty be performed in one week; while for patients with severe closed craniocerebral trauma, the optimal time to perform decompression of the large bone flap due to cranial hypertension caused by a giant skull defect is about three months. In addition to the choice of time for cranial bone repair surgery, the choice of material is also crucial. Good materials not only have better repair results, but also reduce the chance of complications. Currently we use the latest PEEK bionic material, the material’s mechanical and thermal properties are very superior, but also has a high degree of biocompatibility, can perfectly realize the compatibility of the cranial bone symbiosis, is currently safe and effective cranial bone repair materials.