Crooked eye fissures are one of the clinical symptoms of pediatric oculo-auriculo-spinal syndrome. Oculo-auriculo-spinal syndrome, also known as oculo-spinal syndrome, oculo-auriculo-spinal dysplasia syndrome, mandibulofacial hypoplasia-ocular epithelioid cyst syndrome, oculo-spinal hypoplasia, facial-aural-spinal anomalies, and Goldenhar syndrome, is a congenital syndrome with malformations of the eyes, ears, and the face and spine. What tests are required for oculoconiosis? The syndrome occurs in 60% to 70% of cases in boys, and its clinical manifestations are complex. About 10% of cases are mentally retarded, while most cases show only partial signs. The main signs are as follows. 1. Eyes with corneal dermatomas, eyelid defects, ptosis, small corneas and small eyeballs, crooked eye fissures, cataracts, etc. 2.Ear with pars plana, preauricular fistula, deafness and external auditory canal defect. 3.Facial deformities such as small jaw deformity, hare lip, giant mouth (transverse cheek cleft), zygomatic bone hypoplasia, teeth misalignment, etc. 4.Spinal deformity is manifested as different forms of scoliosis and bone healing, but there may also be rib abnormalities, skull deformities, limb and foot deformities. 5.Other malformations may include cardiovascular malformations, lung, kidney, dental and intellectual abnormalities. In the five cases reported by Zhou Daohua et al, all of them were born with onset of disease. Three cases had upper eyelid defects, two cases had small eyeballs and small corneas, and one case had cryptophthalmos without normal intraocular structures. two cases had preauricular malformations and one case had a congenital fistula combined with deafness. one case had a longitudinal scar in the center of the nasal bridge with a scar length of about 18 mm, and the other case had a nasal malformation. X-rays showed scoliosis of the thoracic spine with wedge-shaped healing of the bone. In addition, there were abnormalities such as mental retardation, forehead protrusion, harelip, cleft palate, and misaligned teeth. Histopathological examination of the corneal surface superfluous organisms confirmed corneal dermatoma. The diagnosis was based on the presence of coexisting abnormal signs such as ocular-ear-spinal. Chromosomal examination was normal.