Usually there is no absolute best fever reduction method for high fever, high fever generally refers to the temperature between 39.1 ℃ and 41 ℃, high fever may be caused by respiratory diseases, such as pneumonia, etc.; blood diseases, such as leukemia. Patients can lower the temperature through physical fever reduction, medication and other ways. 1. Pneumonia: For patients with high fever caused by pneumonia, they can use ice to physically cool down the temperature or take warm baths, especially need to wipe the armpits, groin, neck, shoulders and back where the heat is dissipated more quickly to dissipate the heat. Patients can take antibiotics under the guidance of the doctor, such as amoxicillin, cefixime, etc. If the fever does not go down, oral antipyretic drugs, such as acetaminophen, ibuprofen, etc. for symptomatic antipyretic treatment. 2. Leukemia: due to the relatively low resistance of leukemia patients, easy to cause infections with high fever, leukemia patients can drink a small amount of lukewarm water, the use of lukewarm water or alcohol on the forehead or armpits, groin and other large blood vessels parts of the wipe, in order to achieve the purpose of lowering the temperature, the patient can comply with the doctor’s orders to use cefixime, ampicillin and so on. In addition, systemic lupus erythematosus, tumors, appendicitis suppuration and other diseases may also cause high fever, it is recommended that the patient seek medical examination in a timely manner, to clarify the cause of the targeted treatment, in life, patients should strictly comply with the doctor’s instructions to use medication, pay attention to the monitoring of the condition, such as the emergence of convulsions, shock and other reactions, should be promptly consulted for medical treatment.