Just by reading the words “gastroesophageal reflux”, it is easy to think of it as a simple digestive disorder. However, in clinical practice, its manifestations go far beyond the digestive system. In addition to acid reflux, heartburn and belching (commonly known as hiccups), chronic cough, sore throat, asthma, dysphagia and chest pain can all be manifestations of gastroesophageal reflux. Its intraesophageal manifestations are reflux esophagitis, i.e. esophageal erosion, ulceration, stricture, and in severe cases, esophageal adenocarcinoma; its extraesophageal manifestations are reflux pharyngitis, reflux asthma, non-cardiogenic chest pain and non-cardiogenic pneumonia, and it may also be related to allergic cough. The number of organs involved and the mixed symptoms can easily confuse patients and cause delay in consultation. With the increasing number of patients in this segment, it is important for the public to know how to recognize GERD. It is understood that, compared with an ordinary cough, a cough caused by GERD may be accompanied by a feeling of acid reflux in the former, aggravated by coughing at night when sleeping or lying down, ineffective in taking cold and cough medicines, but quite sensitive to medicines that inhibit gastric acid secretion, from which a basic distinction can be made. In case of acid reflux combined with asthma and chest pain with life-threatening manifestations, it is recommended to exclude respiratory and cardiovascular diseases first, and then make a therapeutic diagnosis by the effectiveness of taking drugs to inhibit stomach acid. For those who are in a position to do so, two tests, 24-hour esophageal PH impedance monitoring and high-resolution esophageal manometry, can also be chosen to get a direct conclusion. This type of disease is generally more common in the elderly and is associated with reduced gastrointestinal function in old age. Decreased gastrointestinal motility in fat people also has an effect. But nowadays, probably because of the stress, the clinic sees a lot of young people in their 20s. Young patients usually have several bad habits at the same time, such as emotional stress, poor rest, irregular diet, fondness for smoking and drinking, wearing tight clothes, and sweet tooth, which can be triggers for GERD. Lifestyle changes are the best way to prevent early GERD. To actively exercise, enhance physical fitness, moderate weight loss; try to eat less high-fat meals, chocolate, coffee, candy, sweet potatoes, potatoes, taro; strictly quit smoking and stop drinking alcohol; eat fewer meals, should not lie down immediately after meals, and it is best not to eat 2-3 hours before bedtime; if you are prone to acid reflux at night, it is best to raise the head of the bed 10-20 cm during sleep, or adopt a reclined position. Psychological factors also have a great impact on the digestive system, like anxiety and depression can cause adverse reactions in the digestive system, so it is equally important to pay attention to relieving stress during times of tension. Our center is the only specialized center for GERD in China, with a variety of treatments, including medication, laparoscopic fundoplication, endoscopic micro radiofrequency ablation of the esophagus, etc. Most of the thousands of patients treated at our center have achieved good results after long-term follow-up.