Fat grafting has been widely used in the field of medical aesthetics, and its safe and reliable efficacy has made it a popular cosmetic procedure among beauty seekers by word of mouth. Perhaps this familiarity has led many people to believe that fat grafting is completely harmless, thus neglecting its professional difficulty as a surgical procedure. Fat grafting is contraindicated like other surgeries, for example, patients with organic lesions and mental illness are not suitable for fat grafting; some other conditions increase the risk of surgery, such as high blood pressure, diabetes, oral anticoagulant drugs, bleeding tendency, infected foci and menstrual period, which should be controlled or avoided before fat grafting. Fat grafting has conventional risks such as bleeding, infection and injury. However, compared to other conventional incisions, fat grafting is a minimally invasive procedure with a small wound, and the probability of such risks is low. It is worth noting that fat embolism may occur when fat particles or lipid droplets enter the blood vessels. This places a high technical demand on the surgeon. Especially when it comes to facial fat filler, the doctor should have an in-depth intuitive understanding of the distribution and levels of the vascular alignment of the face, operate gently, inject slowly in points, choose the right injection needle, etc., which helps to reduce the occurrence of complications. It is relatively safe for doctors in regular medical institutions to perform fat filler surgery according to the standard operation procedure. Therefore, we remind candidates who want to have fat transfer filler to choose a regular medical institution for consultation.