B-type pro-brain natriuretic peptide is clinically referred to as amino-terminal B-type natriuretic peptide pro, which, along with B-type natriuretic peptide, is a biomarker of heart failure and is synthesized and released by the myocytes of the heart chambers. If elevated in plasma, the severity of heart failure is proportional to the elevation, which is an indicator for the diagnosis of heart failure and an important reference for the prognosis of heart failure. Amino-terminal B-type natriuretic peptide is highly specific for the diagnosis of heart failure in adults under 50 years of age if it is greater than or equal to 450 pg/mL, and in adults over 50 years of age if it is greater than or equal to 900 pg/mL, heart failure can be diagnosed, and heart failure can be excluded if it is less than 300 pg/mL.