The difference between isoniazid rifampicin is the difference in ingredients, indications, adverse reactions and contraindications. ⒈ ingredients: isoniazid, rifampicin are two different drugs for the treatment of tuberculosis. ⒈ indications: isoniazid has a strong antibacterial effect, mainly for all types and stages of pulmonary tuberculosis and extrapulmonary tuberculosis, isoniazid can be used as the first choice of drugs to prevent and treat tuberculosis. Rifampicin can be used to treat tuberculous meningitis, for leprosy, non-tuberculous mycobacterial infections and so on. 3. Contraindications: patients who are allergic to isoniazid, patients with acute liver disease, psychiatric patients, epileptic patients are forbidden to use isoniazid. Rifampicin is contraindicated in patients who are allergic to rifampicin, those with active Neisseria meningitidis infection, severe hepatic insufficiency and bile duct obstruction. 4. Adverse reactions: Rifampicin may cause adverse reactions such as chills, dizziness, headache, fever, muscle and bone pain. Isoniazid may cause nausea, vomiting, liver injury, anemia, jaundice and other adverse reactions. If you need to use the above drugs, you should use them under the supervision of a doctor.