Focal calcification of the fetal left ventricle is the echogenic enhancement of speckled, focal or striated structures in the fetal left ventricle, which can be single or multiple, commonly at the papillary muscle of the left ventricle, and is a relatively common ultrasound presentation during pregnancy. The formation of calcified foci may be due to thickening of the intraventricular tendon cords, which form a strong echogenic reflection, deposition of minerals in the papillary muscle, calcification, and may be associated with chromosomal abnormalities. If an independent intraventricular calcification spot is found during the ultrasound, if the Down screening result is low risk, observation can be continued and no other special tests are needed, but if, in addition to the intraventricular glaucomatous spot, other organ abnormalities are found in the fetus, further chromosomal examination is recommended. If there is an independent intracardiac spot but the Down screening is high risk, further examination for fetal chromosomal abnormalities is also needed.