The side effects of methylhesperidin mainly include the following three points: first, it can cause psycho-neurological symptoms, such as insomnia, drowsiness, dizziness, headache, anxiety or fatigue, etc. It can also cause gastrointestinal symptoms, which are relatively rare, such as nausea, vomiting, indigestion, abdominal pain, diarrhea, etc. There are also rare skin symptoms, which can cause eczema or pityriasis rosea, which can generally recover gradually after stopping the drug. Clinically methyl hesperidin has the same efficacy as vitamin P, can enhance the effect of vitamin C, and has strong antiviral and antibacterial effects. Large doses can inhibit the reproduction of influenza virus, can inhibit the effect of tyrosinase that causes skin darkening, can be used to treat skin diseases such as dark spots and freckles, has the ability to maintain the normal permeability of blood vessels, improve capillary resistance, enhance capillary elasticity and toughness, prevent and treat capillary bleeding, gum bleeding, etc. In addition, it can also strengthen capillary resistance, normalize capillary osmotic pressure and prevent atherosclerosis. It is more effective when used with vitamin C. It can be used for nasal bleeding, retinal bleeding, gum bleeding, gastrointestinal bleeding and hemorrhoid bleeding.