Generally, omeprazole and amoxicillin in combination with other medications can treat esophagitis caused by Helicobacter pylori. Esophagitis, or esophagitis, is caused by Helicobacter pylori, viruses, fungi and other factors that lead to irritation or damage to the esophageal mucosa, congestion, edema and other inflammatory changes, and in severe cases, can lead to erosion or even ulcer formation. Esophagitis can be manifested as acid reflux, heartburn, swallowing pain, chest pain, and dysphagia. Omeprazole belongs to the proton pump inhibitor, can be irreversibly covalently bound to the proton pump in the gastric mucosa wall cells, so that the proton pump is partially inactivated, thus inhibiting the secretion of gastric acid, reducing gastric acid on the esophageal mucosa damage and corrosion, which is conducive to the alleviation of pain and acid reflux and other symptoms. Amoxicillin belongs to cephalosporin antibiotics, can be used to treat esophagitis caused by H. pylori infection, play the role of anti-inflammatory and bactericidal, reduce the esophageal mucosa localized redness, swelling, erosion and other inflammatory reactions. Helicobacter pylori infection caused esophagitis, in addition to amoxicillin, omeprazole, should also be used in conjunction with bismuth pectin, clarithromycin and so on. It should be noted that both omeprazole and amoxicillin need to be taken under the guidance of a doctor, and should not be used without authorization.