Severe asphyxia in preterm infants has certain effects. Neonatal asphyxia is a disease in which the fetus suffers from intrauterine distress due to oxygen deprivation or respiratory and circulatory disorders during delivery due to a variety of prenatal, intrapartum or postpartum etiologies, resulting in the absence of spontaneous respiration or the failure to establish regular respiration within one minute after birth. Premature infants with severe asphyxia have pale skin, dark purple lips, and no breathing or only wheezing-like weak breathing. Heartbeat is irregular, heart rate <80 beats per minute, and weak. There is no response to external stimuli, muscle tone is flaccid, and the laryngeal reflex is absent. The child appeared asphyxia, there may be certain sequelae, especially the severe asphyxia, due to the baby’s lack of oxygen for a long time, some of the cells of the brain damage, the sequelae will be more serious, will affect the baby’s intellectual development of the brain, and may even form a cerebral palsy, triggered by cerebral hemorrhage, causing fatal injuries to the preterm infants, and so on. If the situation of severe asphyxia in premature babies occurs, please contact the doctor in time to deal with it, observe the baby’s condition more, and actively cooperate with the doctor for treatment to avoid adverse consequences.