When the body temperature exceeds 39 degrees Celsius or 40 degrees Celsius, symptoms of heat stroke such as sweating shutdown, dizziness and headache, and mental disorders often occur, and respiratory failure can occur within a few hours in severe cases. The common causes of sweat closure: 1, congenital sweat gland dysplasia or lack of sweat glands, can be manifested as a generalized or restricted sweating. 2, Certain skin diseases, such as severe ichthyosis, scleroderma, leprosy, radiation dermatitis, skin atrophy, etc., can cause restricted anhidrosis. 3, Nerve injury, such as transverse myelitis, pediatric paralysis, paraplegia, and local injury to the sympathetic nerve, medulla oblongata, and pontine brain, can cause generalized or restricted anhidrosis. 4, certain visceral disorders, such as diabetes, uremia, chronic nephritis, mucinous edema, malignant tumors, etc. In addition, vitamin A deficiency, etc., can also cause generalized anhidrosis.