According to statistics, about 76% of the population is found to have thyroid nodular disease during ultrasound examination, of which, 5%-15% are malignant. The accuracy of conventional ultrasound for the identification of benign and malignant thyroid nodules is less than 90%. In order to find ways to improve the identification of benign and malignant thyroid nodules, the technique of puncture biopsy was conceived. A puncture biopsy is a method of obtaining cells or tissues in the suspected area for pathological diagnosis. It has the advantages of less damage to the human body, easy operation, rapid and inexpensive, and is a safer and more effective way. At present, the trinity of conventional ultrasound, flexible ultrasound and puncture biopsy technology is used to diagnose thyroid nodules in a three-dimensional diagnostic mode at DCH. The puncture biopsy technique is the final and most important part. The combination of puncture biopsy and ultrasound has greatly improved the accuracy of differentiating benign and malignant thyroid nodules, making it possible to reach 99%. Radiofrequency ablation treatment wins the favor of nodule patients, to meet the woman’s love of beauty thyroid nodules is a common disease, in recent years the detection rate of thyroid nodules show a year-on-year increase, its malignant rate of 10-20%. Traditional treatment methods include surgery, TSH suppression therapy, radioactive iodine therapy, etc. Radiofrequency ablation technology, as an emerging treatment method, uses thermal energy to cause coagulative necrosis of thyroid nodules in situ to treat thyroid nodules, which is minimally invasive, effective, short treatment time, small side effects, few complications, and aesthetics, even though neurothermal injury and bleeding are the main risks, but the incidence is extremely low under ultrasound surveillance, which is the preferred treatment method for patients with benign thyroid nodules and is being accepted and recognized by more and more patients and friends.